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Kenya to commence HIV vaccine human trial in July ▷ Kenya News

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A vaccine with the potential to stop HIV infecting cells is set to be launched in Kenya with the clinical human trials starting in July 2019.

According to an announcement made by a group of scientists on Friday, June 14, the recruitment for the promising trial would begin in the next three weeks.

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HIV test kit. The new vaccine will apply a ‘block approach’ in stopping HIV from attaching itself onto cells.
Source: UGC

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The new vaccine will apply a ‘block approach’ in stopping HIV from attaching itself onto cells, specifically the CD4 cells, often called T-cells which forms part of the immune system.

The clinical trial has been codenamed IAVI W001 trial.664gp140. W001 and will test a vaccine candidate dubbed BG505 SOSIP — a molecule cloned to look exactly as the HIV one.

The director of Kenya AIDS Vaccine Initiative (KAVI), Omu Anzala, said the trials will be tested on HIV-negative Kenyan volunteers to check for safety and efficacy, Daily Nation reported.

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“This is phase one of the first human trial for this vaccine and over the next one-and-a-half years, the trial will seek to answer questions on how safe the vaccine is and how well it can induce the human body to produce antibodies that can neutralise HIV,” said Anzala.

“The candidates (HIV-negative), will get three shots every month for the first three months … and then we will start to keenly follow them up … to see did it work or not,” he explained.

This was after the trial vaccine showed promising results by causing production of antibodies that neutralised a HIV-like virus during animal testing.

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Senior research scientist at the International Aids Vaccine Initiative (IAVI) who developed the molecule BG505 SOSIP. 664gp140, said it belongs to a new generation of immunogens molecules.

Elise Landais said that the molecules are capable of causing an immune response in the body called nativelike trimers.

They induce broadly neutralising antibodies with capacity to attack the HIV virus in the body upon detection.

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“So BG505 SOSIP. 664gp140 is the molecule that will be put in the test candidates by vaccination,” said Dr Landais.

“This is the first time we’re trying anything like this. Before the molecule, we were working with HIV products that we discovered recently weren’t very good at achieving the desired results,” she added.

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But the scientist claimed they now know the right shape of the molecule that sits on the HIV virus and hence this trial.

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Before, the scientist were looking at a certain shape of immune cells that were killing the infected ones.

This time round they are focusing on activating cells that are going to produce antibodies that will actually block the virus even before it infects the cells.

“So instead of coming after the infection has already happened, we are trying to block its pre-infection. All the products we had before couldn’t activate this kind of response because it did not have the right shape,” she said.

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Anzala also said this is a new product and that previously, they used products that elicit T-cells, but this particular product is eliciting humoural immunity or B-cells that will give broad and potent neutralising antibodies.

The researchers spoke during a scientific talk at the University of Nairobi College of Health Sciences’ KAVI-Institute of Clinical Research.

Relevant infrastructure and technology transfer for the trial had been concluded at the site.

Do you have a hot story or scandal you would like us to publish, please reach us through news@tuko.co.ke or WhatsApp: 0732482690 and Telegram: Tuko news.

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Famous people who became successful after 40 : The Standard

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Not everyone has their lives figured out by the time they hit 30. To many, this is a defining age that should go down with a stable career, a home and even a car.

But people hack it in life at different ages. It may be success at such a tender age as that achieved by 29-year-old Juliette Brindak, an American whose billion-dollar fun website was developed when she was only 14.
Success may also be realised later in life the same way that Harry Bernstein, a celebrated British writer, made his first breakthrough at 96. Bernstein authored countless books that gathered dust at the publishers’ before getting attention later in life. His first book to be published, The Invisible Wall: A Love Story That Broke Barriers, would precede three others in a row before the British writer of Jewish descent died at 101.
When he died, the New York Times profiled the author whose memoir detailing a life of poverty and struggles earned him belated literary fame on its publication in 2007.

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Bernstein is not an isolated case on the list of people who found success late in life, after countless hurdles. Here, we provide more examples that not everyone hits their peak in their 20s. Hopefully, they are inspiring accounts that prove you don’t need to panic that others are succeeding while you are not, despite your hard work and dedication.
Julia Child
Julia Child was an American chef, author and television personality who didn’t hack it until she was 51. At this age, she introduced French cuisine on American television after releasing countless cookbooks.

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Before this, Julia traversed continents working as a clerk for the intelligence agency of the United States during World War II.
While working with the American intelligence unit, Julia developed a shark repellent by cooking various concoctions that would be adopted by the United States Navy in the Pacific Ocean during World War II.

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The concoction is said to have been her first real attempt in cooking.
A cooking icon, Julia never learnt to cook until she met her husband. It is said that her husband who loved home-made food enticed her into trying out recipes at home. She then enrolled for cooking classes and even joined cooking groups to get additional skills.
Lynda Weinman
At 40, Lynda Weinman founded Lynda.com, an online teaching library that would later be bought by LinkedIn, a professional networking platform.
The innovation was born out of several stints in graphic arts, both in employment and as an independent contractor.

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Ms Weinman worked as a graphic arts professor and in the film industry as a special effects animator. She also worked as an independent contractor doing animation and special effects where she worked on several films.
She would later procure a computer lab that eventually turned into an online learning platform with more than 6,300 online classes and 267,000 video tutorials. Lynda.com teaches computer skills in video format to members through monthly and annual subscription-based plans.
A self-taught career woman profiled on Forbes as ‘the Mother of the Internet’,  Ms Weinman made an interesting twist from her career in humanities to a new found interest when she taught herself to operate a home computer using a manual.
One of the failures she sailed through, which she disclosed in an interview with Forbes is losing every penny of a $20,000 loan she received from her grandfather to start a retail store.
Henry Ford

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In the automobile industry, most people know about the Ford brand of the Ford Motor Company.
What’s hidden from most, however, is the story behind the American multinational automaker founded in the early 90s by Henry Ford.
Likewise, the story of Henry Ford is an open book to read especially by those seeking to keep their dream on course. Ford didn’t wake up one morning to unveil the Ford Motor Company and neither was the journey towards achieving the dream of owning an automobile easy.
In his youth, Ford worked as an engineer under Thomas Edison, where for many years he set aside a few hours to work on ways to improve the then new automobile.
It was not until he was 40 that he founded the Ford Motor Company, which now sells all types of automobiles.
Charles Darwin
Charles Darwin is a name engraved in those of us who studied science in school. Our knowledge of him, however, might not go beyond the man who tried to prove where human beings came from in his studies of evolution by natural selection.
Darwin was not the famous person we know today until very late in life. It wasn’t until he hit 50 that he finally published the Origin of Species.
This was after countless years spent on expeditions, most of the time exploring on land and sea.
He is also known to have kept to himself all this while, researching on geology. It is in this silence that he is said to have a developed the art of theorising.
Here is one of Darwin’s most powerful and inspirational quotes that could help you build resilience as you wait for your breakthrough: “It is not the strongest of species that survives. Nor the most intelligent that survives. It is the one that is most adaptable to change.”
Harland Sanders
If you find Kentucky Fried Chicken (KFC) delicacies irresistible, then you must find the background of its founder equally salacious.
Harland Sanders was 65 when he saw his restaurant that served fried chicken fail. But Sanders never gave up until he saw the restaurant become the biggest fast food chain in the world.
And now, KFC, which is headquartered in Kentucky, is the world’s second largest fast food restaurant that specialises in fried chicken.
Few know that KFC was born in a humble roadside restaurant where Harland Sanders sold pressure-fried chicken pieces with a special seasoning of herbs and spices.
Out of a need to take care of his siblings and single mother, Sanders learnt how to cook professionally when he was only seven.
He started his first eatery, which passed for an amateur restaurant, at a Shell filling station in Kentucky.
On this one-table restaurant, he served fried chicken and other dishes. He accumulated enough to expand to a six-table restaurant, still at the filling station and later to 142 seats. This is the time he purchased his first motel, seven years after his first ever stint in the industry.
KFC grew gradually and 20 years later, it had 600 restaurants, making it the largest fast food outlet in the United States.
Today operating in more than 20, 000 locations across the globe, KFC offers a variety of other chicken products including chicken fillet sandwiches, salads and other side dishes.  
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How to secure your privacy on your phone : The Standard

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Some of us have been using android phones for the longest time yet there are some settings we don’t know about that can really be helpful.

Ever wondered how ads related to what you’ve been searching for online always seem so spot on? This is because Google actually tracks your movement online and serves you up with ads they think are relevant to you. This can be embarrassing at times, to say the least, and a gross violation of privacy for some. 
To stop Google from using your personal information to serve you ads, you can go to settings options on your phone, choose ads and opt out of ad personalisation in the menu that follows.
As for privacy and security especially for those who handle sensitive data on your phone, listen up. Did you know that most phones don’t lock your screen immediately after you press the power button? What they do is only turn off the screen. This means that there is a chance that anyone who picks up your android phone shortly after that can actually get access to the phone and data therein.

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To make sure this doesn’t happen, go to settings option then pick security, choose screen lock settings, tap on the gear icon and turn on “power button instantly locks” button. This will ensure that your screen locks as soon as you press the power button.
The third setting on security and privacy is actually one concerned with Google Voice Assistant. The voice assistant is brilliant as a tool for your convenience – the ability to perform almost all your phone’s functions using nothing but your voice is very useful.
How it works is say the words “OK Google” and give a command. The app is designed to bypass your screen lock when it picks up the keyword. Unfortunately, this doesn’t always happen; Google Assistant can misinterpret your words and sometimes activate the screen bypass even when you don’t say the keywords “OK Google”.

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This is bad for security as someone can mimic your voice and unlock your phone. To avoid this, go to the Google app, choose menu or three dots on your top left, then pick settings, voice then look for OK Google detection and turn off the trusted voice feature.   


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Hustlers aren’t always honest : The Standard

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The image of a hustler as a patient, persistent and hardworking citizen is often punctuated by the reality of men and women who take shortcuts.

In fact, one reason many hustles die is because of dishonest hustlers. They’ll sell you pishori rice, which is only pishori at the top. If it’s all real, it will become less real the more frequently you buy.
They will sell peas with half the bucket filled with sack cloth. They’ll tamper with weighing machines to sell you less meat. They’ll sell you contaminated petrol or cook chips with transformer oil.
One hustler took six months to import a car for me. We can add the list – I’m sure most readers of this column have been victims of dishonest hustlers.

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Whether in the city or in rural areas, dishonest hustlers give honest ones a bad name.
Customers aren’t that foolish; they discover your shortcuts and disappear. You’ll be left with first-time customers and your base will never grow. Instead of graduating to a formal business, giving you time to rest, you’ll stagnate. Instead of graduating from hustling and leaving it to the next generation, you prolong your struggle.
Great asset

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Great business empires are built on honesty. It takes longer to make money honestly, but the money lasts longer and can flow on to the next generation. If you’re honest and customers trust you, you’ll thrive and grow a business you can leave to your progeny.
That’s how Ford, Toyota and other famous brands have remained with families either as managers or shareholders.

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Honesty can be a great asset in your hustle. Think of why you leave your Sh10 million car in the hands of a hustler – or your children in the care of a househelp.
Sadly, taking shortcuts, conning and outright theft without being caught are celebrated. No wonder huge multinational firms are rare in Kenya.
Westerners and Easterners are perplexed by our propensity to take shortcuts, and then we complain that the economy isn’t growing, that there are no jobs and that insecurity is rife. Is it our upbringing? Is it our schools? Is it our religions or governance?
The cost of dishonesty is high and even intergenerational. Individuals, families and the whole nation pay. What if we had more honest hustlers? Suppose we made honesty instead of dishonesty the badge of honour? Suppose we made honesty part of the hustler’s culture?
Are you an honest hustler? If yes, keep up. If not, the market will deal with you sooner rather than later ….  

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